DSCF1662 - copy
Welcome to the lab
DSCF1662
We combine blue sky science, technologies and translational research
previous arrow
next arrow

Krasileva Lab

Full description of lab culture - see Krasileva Lab Charter

231 Koshland Hall, Berkeley CA 94720 kseniak [at] berkeley.edu.

Upcoming presentations

This year, we will be attending: The Plant & Animal Genome Conference,  Fungal Genetics, Biology of Genomes, Gordon Research Conference on Cellular and Molecular Fungal Biology, International Plant Protection Congress, iCAR, Plant Pathology 2024

Main Presenter - Title - Conference information

Ksenia Krasileva - Evolution in Overdrive: Decoding and Encoding Genomes for Disease Resistance - Plant Pathology 2024, Oxford, UK

Chandler Sutherland - Distinct genomic features are associated with the rapid evolution of NLR receptors in Arabidopsis and Maize - Plant Pathology 2024, Oxford, UK

Past talks (recorded)

Scientific conferences and seminars

Chandler Sutherland - "Contributions of Mutation and Selection to the Rapid Evolution of Plant Innate Immune Receptors" - Biology of Genomes 2024 - link to recording (15 min talk plus Q&A)

Pierre Joubert - "Catching up to Fungal Plant Pathogens" - Pierre Joubert Dissertation Finishing Talk, May 15, 2023 - link to recording (1 hr seminar)

Kyungyong Seong - "Elucidating effector evolution through predicted structures" MPMI Virtual Seminar - Best MPMI Graduate Student Paper Award - link to recording (30 min seminar plus Q&A)

Ksenia - "Comparative structural genomics of pathogen effectors and plant immune receptors: from natural diversity to precise modification" UC Riverside, Sept 30th, invited seminar - link to recording  (1 hr seminar)

Pierre Joubert - "Characterizing the extrachromosomal circular DNAs of Magnaporthe oryzae and their potential role in adaptation" - The 31st Fungal Genetics Conference, March 15-20 2022 - link to recording (15 min talk)

Erin Baggs - "Lessons from loss; plant immune signaling pathways and pathogen interactions from land to water" - PhD finishing talk, January 13th - link to recording (46 min seminar with intro by Ksenia)

Outreach

Chandler Sutherland - "How Plants Evolve Their Immune System" The Graduates radio podcast, hosted on on KALX 90.7 link to recording

Chandler Sutherland - "It's Not Easy Staying Green: Understanding Plant Immune Systems" Ask a Science Envoy, hosted by Wonderfest: Bay Area Beacon of Science. " link to recording

Fraces (Grace) Stark - "Fungal Immune Systems with Grace Stark" - Central Texas Mycological Society, Nov 18th 2021 7-9PM CT invited talk. Open to public with livestream on Youtube - link to recording (~1 hr 30 min with discussion)

Who we are and what we do

Krasileva lab an inter-disciplinary group of people. Our common goal is to understand innate immunity; currently we are working with plants and fungi. We focus on evolution and function of immune genes, as well as the mechanisms that regulate genetic diversity. To read more about specific research projects visit About us and Publications.

The lab is located in Koshland Hall, we are part of Department of Plant and Microbial Biology as well as the Innovative Genomics Institute and The Center for Computational Biology at the University of California Berkeley.

If you are interested in joining the lab:

Undergraduate research: reach out to us directly before the semester begins or look for projects at URAP and SPUR.

Graduate students: we are part of graduate programs in Microbiology and Plant Biology as well as Center for Computational Biology. To discuss a rotation, please reach out a few weeks in advance.

Postdocs: please send Ksenia your CV and a list of postdoc fellowships you would like to apply for.

Staff: occassionally, positions become available. Please, watch this space or send us a note.

Our lab culture, summarized in the Krasileva Lab Charter, is built on honesty and transparency and open communication. We aim to maintain the highest quality of research and strongest work ethic without sacrificing our health or wellbeing of our families. If you have any questions about Krasileva Lab, do not hesitate to reach out to any lab members.

Lab News

August 2024

We bid farewell to Rakesh Kumar who has been a postdoc and then staff scientist in the lab for the past two years. Rakesh is moving to USDA, Albany. Rakesh will stay as an affiliate with the lab and continue working on wheat, including some joint projects.

The 9th annual Krasileva Lab retreat, 2024 was at the Russian River. We forward planned our year, discussed strengths, weaknesses, opportunities and threats in the lab, cooked, hiked and enjoyed time together.

New and updated lab publications and pre-prints!

Kyungyong Seong, Wei Wei, Brandon Vega, Amanda Dee, Griselda Ramirez-Bernardino, Rakesh Kumar, Lorena Parra, KseniaKrasileva "Engineering the plant intracellular immune receptor Sr50 to restore recognition of the AvrSr50 escape mutant"

Prigozhin DM, Sutherland CA, Rangavajjhala S, Krasileva KV. "Majority of the highly variable NLRs in maize share genomic location and contain additional target-binding domains". Mol Plant Microbe Interact. 2024 Jul 16. doi: 10.1094/MPMI-05-24-0047-FI. Epub ahead of print. PMID: 39013614

China Lunde, Kyungyong Seong, Rakesh Kumar, Andrew Deatker, Bhavit Chhabra, Meinan Wang, Shivreet Kaur, Sarah Song, Ann Palayur, Cole Davies, William Cumberlich, Upinder Gill, Nidhi Rawat, Xianming Chen, Meriem Aoun, Christopher Mundt, Ksenia V Krasileva "Wheat Enhanced Disease Resistance EMS-Mutants Include Lesion-mimics With Adult Plant Resistance to Stripe Rust" bioRxiv 2024.05.10.593581; doi: https://doi.org/10.1101/2024.05.10.593581

March and April 2024

New and updated lab publications and pre-prints!

Prigozhin DM, Sutherland CA, Rangavajjhala S, Krasileva KV "Majority of the highly variable NLRs in maize share genomic location and contain additional target-binding domainsbioRxiv 2022.10.05.510735; doi: https://doi.org/10.1101/2022.10.05.510735 Research article v2

Sutherland CA, Prigozhin DM, Monroe JG, Krasileva KV. "High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features". EMBO Rep. 2024 Mar 25. doi: 10.1038/s44319-024-00122-9 Research article

Schuster M, Schweizer G, Reißmann S, Happel P, Aßmann D, Rössel N, Güldener U, Mannhaupt G, Ludwig N, Winterberg S, Pellegrin C, Tanaka S, Vincon V, Presti LL, Wang L, Bender L, Gonzalez C, Vranes M, Kämper J, Seong K, Krasileva K, Kahmann R. Novel Secreted Effectors Conserved Among Smut Fungi Contribute to the Virulence of Ustilago maydis. Mol Plant Microbe Interact. 2024 Mar;37(3):250-263. doi: 10.1094/MPMI-09-23-0139-FI. Epub 2024 Apr 3. PMID: 38416124. Research article

E. Thynne, H. Ali, K. Seong, M. Abukhalaf, M. A. Guerreiro, V. M. Flores-Nunez, R.Hansen, A. Bergues, M. J. Salman, J. J. Rudd, K. Kanyuka, A. Tholey, K. V. Krasileva, G. J.Kettles, E. H. Stukenbrock "An array of Zymoseptoria tritici effectors suppress plant immune responses" bioRxiv 2024.03.12.584321; doi: https://doi.org/10.1101/2024.03.12.584321 Research article

February 2024

Led by China Shaw, the Krasileva Lab hosted students from Latitude High School in Fruitvale. Students toured the lab, saw tomatoes expressing the marker gene RUBY, toured the UC Berkeley Bioimaging Facility and attended a science career panel.

We have also said good bye to visiting student Giuseppe Denora who was mentored by Rakesh Kumar

Krasileva Lab News recaps

2023 lab news recap - link

2022 lab news recap - link

2021 lab news recap - link

2020 lab news recap - link

2019 lab news recap - link