DSCF1662 - copy
Welcome to the lab
We combine blue sky science, technologies and translational research
previous arrow
next arrow

Krasileva Lab

Black lives matter

231 Koshland Hall, Berkeley CA 94720 kseniak [at] berkeley.edu.

Upcoming science presentations at conferences and symposia

Main Presenter - Title - Conference information

In 2022-2023, lab members will be attending and presenting at the International Conference on Plant Synthetic Biology, Bioengineering and Biotechnology, The Plant and Animal Genomics, The Biology of Genomes, The Molecular Plant Microbe Interaction Congress, APS Plant Health 2023 and maybe more. Watch this space for the announcements.

Wei Wei - "Utilizing transcriptional control to engineer crops with broad-spectrum disease resistance and
less fitness cost" - International Conference on Plant Synthetic Biology, Bioengineering and Biotechnology, Dec 2022, poster

Ksenia - "From Natural Diversity to Engineering: Rational Optimization of Wheat Disease Resistance Genes" - The Plant and Animal Genomics, New Approaches for Developing Disease Resistance in Cereals Workshop, January 2023, invited talk

Daniil Prigozhin - TBC - The Plant and Animal Genomics, Plant Disease Resistance Workshop, January 2023, invited talk

Chandler Sutherland - TBC - The Plant and Animal Genomics, Mutation Workshop, January 2023, invited talk

Rakesh Kumar - TBC - The Plant and Animal Genomics, Translational Genomics Workshop, January 2023, invited talk

Ksenia - "Biodiversity of plant innate immune receptors and pathogen effectors" - The Molecular Plant Microbe Interaction Congress, July 2023, plenary talk

Past talks (recorded)

Kyungyong Seong - "Elucidating effector evolution through predicted structures" MPMI Virtual Seminar - Best MPMI Graduate Student Paper Award - link to recording

Ksenia - "Comparative structural genomics of pathogen effectors and plant immune receptors: from natural diversity to precise modification" UC riverside, Sept 30th, invited seminar - link to recording

Ksenia - "From understanding natural diversity to precise modifications of plant immune receptors" - The Donald Danforth Plant Science Center, USA, March 2022 - link to recording (1 hr talk, director's cut, w/ opening in support of Ukraine)

Chandler Sutherland - "It's Not Easy Staying Green: Understanding Plant Immune Systems" Ask a Science Envoy, hosted by Wonderfest: Bay Area Beacon of Science. " link to recording

Pierre Joubert - "Characterizing the extrachromosomal circular DNAs of Magnaporthe oryzae and their potential role in adaptation" - The 31st Fungal Genetics Conference, March 15-20 2022 - link to recording (15 min talk with 4 min of questions)

Fraces (Grace) Stark - "Elucidating Fungal Immune Receptors and Testing the Potential Role of Nucleotide-binding Domain Leucine-rich Repeat-like Proteins (NLR-like) Against Bacterial Antagonists" - The 31st Fungal Genetics Conference, Asilomar March 15-20 2022, selected talk (check here later for a link to recording)

Erin Baggs - "Lessons from loss; plant immune signaling pathways and pathogen interactions from land to water" - PhD finishing talk, January 13th - link to recording (46 min with a 3 min intro by Ksenia)

Fraces (Grace) Stark - "Fungal Immune Systems with Grace Stark" - Central Texas Mycological Society, Nov 18th 2021 7-9PM CT invited talk. Open to public with livestream on Youtube - link to recording (~1 hr 30 min with discussion)

Ksenia - "Plant immune receptors, pathogen effectors and the evolutionary game of 'Go' that they play", North Carolina State University, Nov 1st 2021. invited seminar - link to recording (director's cut 55 min, with introduction by Prof Peter Balint-Kurti)

Ksenia - Catching the right mutation - enhanced disease resistance mutants in wheat protect against stripe rust and other pathogens, America Phytopathological Society, 2021 - link to recording (12 min)

Ksenia - The highly variable plant immune receptors and how to catch them, iCAR, 2021 - link to recording (9 min)

Who we are and what we do

Krasileva lab an inter-disciplinary group of people who combine new technologies, basic and translational research. Our common goal is to understand innate immunity, a system that maintains plant health. We focus on evolution and function of immune genes, as well as the mechanisms that regulate genetic diversity in plants and fungi.

The lab is located in Koshland Hall, we are part of Department of Plant and Microbial Biology as well as the Innovative Genomics Institute and The Center for Computational Biology at the University of California Berkeley.

If you are interested in joining the lab, here is how you can approach us:

    • undergraduate research: reach out to us directly before the semester begins or look for projects at URAP and SPUR.
    • graduate students: we are part of graduate programs in Microbiology and Plant Biology as well as Center for Computational Biology. To discuss a rotation, please reach out a few weeks in advance.
    • postdocs: please send Ksenia your CV and a list of postdoc fellowships you would like to apply for.
    • staff: occassionally, positions become available. Please, watch this space or send us a note.

To read more about specific research projects visit About us and Publications.

My aspiration is to build the lab based on honesty and transparency, to ensure open communication and to maintain the highest quality of research and strongest work ethic without sacrificing our health or wellbeing of our families. Our lab culture is summarized in the Krasileva Lab Charter

If you have any questions about Krasileva Lab, do not hesitate to contact me.

- Ksenia

Lab News

October 2022 - Recent publications, preprints and upcoming talks

This month we are celebrating:

NB! upcoming talk alert. MPMI Awardee Kyungyong Seong will present his computational structural genomics work at the Virtual MPMI Seminar Series. November 15, 2022 at 10AM CST - Register Now

September 2022 - Congrats Erin and Mark on a new research paper

Congratulations to postdoc from the lab Erin Baggs on new research paper. You can read the press release here: "New findings detail alternative immune pathways in duckweed species"

  • Baggs, E.L., Tiersma, M.B., Abramson, B.W., Michael, T.P. and Krasileva, K.V. (2022), Characterization of defense responses against bacterial pathogens in duckweeds lacking EDS1. New Phytol. https://doi.org/10.1111/nph.18453

July 2022 - Congrats Kyungyong on the best grad student author paper, Science art by Dr Lorena Parra

Congratulations to the graduate student Kyungyong Seong for receiving MPMI Graduate Student Paper Award for 2021 for his paperComputational structural genomics unravels common folds and novel families in the secretome of fungal phytopathogen Magnaporthe oryzae. This award goes to the best paper published in MPMI by a graduate student first author.

"Your approach using structure modeling to identify effector families by their folded shape, rather than amino acid sequence opens up a world of possibilities, not only in identifying new effectors but also in understanding the evolution of effector families and functions, and, in the future, as a tool in immune receptor engineering. In addition, your paper was clearly and logically written, with implications and future uses of this approach clearly visualized and explained." -Jeanne Harris, Editor in chief, MPMI.

We also have new science art from the lab. Dr Lorena Parra depicted devastating wheat pathogens that we work on in these wonderful pastel drawings: wheat blast (Magnaporthe oryzae, left) and wheat stripe rust (Puccinia stiiformis f.sp. tritici, right)

May 2022 - new preprint! (yes, we know, we keep writing them)

We have more exciting new research. Do you remember our previous article on computational structural genomics in Magnaporthe oryzae? Here is the part two of this research. If you have not done this already, go and read about comparative computational structural genomics across many fungal pathogens.

March 2022 - read new preprints from the lab

This has been an unprecedentedly productive start of the year. We have exciting new research coming out. Apologies, I have been disturbed by all ongoing events and Slacking to update this website. Here are links to two new lab led preprints!

Read them! Review them openly! Send authors your comments and thoughts, do tell what you liked, what you wished for to be included.
In the meantime, I stand with Ukraine,

January 2022 - Congratulations Kyungyong and welcome new UGs

In a latest collaborative preprint, Kyungyong describes his quest for high quality genome of a highly heterozygous wild tomato (reservoir of disease resistance, it also smells nice and very unique). Kyungyong presents it as a resource for the community, and also in depth unique exploration of NLR diversity on haplotype level. This preprint marks the 25th publication since the establishment of Krasileva Lab in December 2014.

This month, we also welcome a new cohort of the undergraduate apprentices. Welcome William, Mari, Marcus, and Duke. Sarah Song and Anne Nakamoto continue their studies, Sarah rapidly learning comparative plant genomics, and Anne focusing on her senior thesis on Magnaporthe comparative genomics.

Krasileva Lab News recaps

2021 lab news recap - link

2020 lab news recap - link

2019 lab news recap - link